Prognostic Value of D-Dimer/Fibrinogen Ratio in the Adverse Outcomes of Patients Hospitalized for Heart Failure

Abstract

Aim: To evaluate the clinical value of plasma D-dimer/fibrinogen ratio (DFR) in patients hospitalized for heart failure (HF). Methods: Clinical data of 235 patients were retrospectively analyzed. Kaplan–Meier method and Cox regression analysis were used to identify significant prognosticators. Results: The Kaplan–Meier analysis showed that a higher DFR level was significantly associated with an increase in the end point outcomes, including HF readmission, thrombotic events and death (log-rank test: p < 0.001). The multivariate Cox regression analysis showed that the high tertile of DFR was significantly associated with the study end points (HR: 2.18; 95% CI: 1.31–3.62; p = 0.003), compared with the low tertile. Conclusion: DFR is a reliable prognostic indicator for patients hospitalized for HF.

Keywords:

• D-dimer
• D-dimer/fibrinogen ratio
• fibrinogen
• heart failure
• prognosis

Author contributions

T-J Zhao, L-D Bi, J Li and C-Y Tan collected data, T-J Zhao and Q-K Yang analyzed and interpreted the data from the statistics and wrote this manuscript. Z-L Miao provided professional support and revised the manuscript. All authors read and approved the final manuscript.

Acknowledgements

The authors are thankful to J Meng for his continuous support in data collection.

Availability of data and materials

The datasets to replicate the results of this study are available from the corresponding author only on reasonable request.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The present study was performed in accordance with the World Medical Association Declaration of Helsinki and was approved by the Ethics Committee of our hospital. This study was a retrospective study and all the data used for the final analysis was anonymous. Therefore, the informed consent from the enrolled patients was waived. The institutional review board of our hospital gave the ethical approval for this study.