Correlation Between BTG3, Casp9 and Lrp4 Single-Nucleotide Polymorphisms and Susceptibility to Papillary Thyroid Carcinoma

Abstract

Objective: To study the association of BTG3, CASP9 and LRP4 single-nucleotide polymorphisms with susceptibility to papillary thyroid carcinoma (PTC). Methods: The BTG3 rs9977638, CASP9 rs884363 and LRP4 rs898604 genotypes of 175 PTC patients and 175 controls were analyzed. Results: Rs9977638 TC genotype and CC genotype, rs884363 CC genotype and rs898604 GG genotype were related to a lower PTC susceptibility risk (p < 0.01). The risk of PTC susceptibility was higher when carrying BTG3 rs9977638 CC, CASP9 rs884363 AC and LRP4 rs898604 AG at the same time (p < 0.01). Conclusion: Combined BTG3, CASP9 and LRP4 genotype analysis has a certain application value in the diagnosis of PTC.

Keywords:

• BTG3
• CASP9
• LRP4
• papillary thyroid carcinoma
• single-nucleotide polymorphism

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

Written informed consent was obtained from each patient, and the experimental procedures were in accordance with the guidelines of the Ethics Committee of Inner Mongolia People's Hospital, Hohhot, China. The present study was approved by the Ethics Committee of Inner Mongolia People's Hospital, Hohhot, China (202000406L).

Data sharing statement

The data of this study are available from the corresponding author on reasonable request.