IL6R Gene Polymorphisms and Their Relation to Chronic Obstructive Pulmonary Disease Susceptibility in the Chinese Population

Abstract

Background: This work was designed to explore the correlation between IL6R polymorphisms and chronic obstructive pulmonary disease (COPD) susceptibility. Methods: Agena MassARRAY was used to genotype five SNPs of IL6R in 498 patients with COPD and 498 controls. Genetic models and haplotype analysis were used to assess the associations between SNPs and COPD risk. Results: Rs6689306 and rs4845625 increase the risk of COPD. Rs4537545, rs4129267 and rs2228145 were related to a decreased risk of COPD in different subgroups. Haplotype analysis revealed that GTCTC, GCCCA and GCTCA contributed to a reduced risk of COPD after adjustment. Conclusion:IL6R polymorphisms are significantly associated with COPD susceptibility.

Keywords:

• case-control study
• chronic obstructive pulmonary disease
• COPD
• IL6R
• polymorphisms

To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/bmm-2022-0342

Author contributions

Y Ding and T Xie designed this study protocol and supervised the study; H Wu and C He drafted the manuscript; Y Fu and Y Zheng performed the DNA extraction and genotyping; R Mo, L Zhang and J Zhao performed the data analysis; B Zhang and Q Lin performed the sample collection and information recording. All authors read and approved the final manuscript.

Acknowledgements

The authors thank all individuals for their participation and are grateful to the hospital staff for collecting blood samples and clinical information.

Financial & competing interests disclosure

This study was funded by the Hainan Provincial Natural Science Foundation of China (819QN354), National NaturalScience Foundation of China (no. 82160011) and the National Key Research and Development Program of China (2018YFC2002304). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval from the Medical Ethics Committee of Hainan Provincial People's Hospital and have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.