High-Density Lipoprotein-Related Inflammatory Indices Predict Repeat Revascularization in Coronary Drug-Eluting Stenting

Abstract

Background: HDL-C-related inflammatory indices are potential predictors of repeat revascularization (RR) after coronary drug-eluting stenting. Methods: Multivariable Cox regression with restricted cubic splines and receiver operating curve was used. Results: The median follow-up was 50 months. A total of 521 (35.42%) patients experienced RR. The incidence of RR was positively associated with the monocyte-to-HDL-C ratio, neutrophil-to-HDL-C ratio and lymphocyte-to-HDL-C ratio (log-rank p < 0.05). After being fully adjusted, the largest tertile of monocyte-to-HDL-C ratio, neutrophil-to-HDL-C ratio, white blood cell-to-HDL-C ratio and lymphocyte-to-HDL-C ratio increased the risk by 38, 30, 28 and 37%, respectively. Monocyte-to-HDL-C ratio was dose-responsive and linearly correlated with RR. HDL-C-related inflammatory indices had over 60% predictive ability. Conclusion: HDL-C-related inflammatory indices independently predicted RR after coronary drug-eluting stenting.

Keywords::

• coronary artery disease
• drug-eluting stenting
• high-density lipoprotein-cholesterol
• inflammation
• repeat revascularization

Author contributions

Conceptualization: L Ma and X Guo. Methodology: X Guo and R Shen. Formal analysis and investigation: X Guo and R Shen. Writing (original draft preparation): R Shen. Writing (review and editing): Y Su. Funding acquisition: L Ma. All authors contributed important intellectual content to this study. All authors read and approved the final manuscript.

Financial disclosure

The investigation of this work was supported by the National Key R&D Program of China (grant no. 2021ZD0111003), Capital’s Funds for Health Improvement and Research from the Beijing Municipal Health Commission (grant no. SF 2022-2-4035) and the Capital Health Development Project of China grant (grant no. SHF-2016-2-4032). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Competing interests disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

Additional information

Funding

The investigation of this work was supported by the National Key R&D Program of China (grant no. 2021ZD0111003), Capital’s Funds for Health Improvement and Research from the Beijing Municipal Health Commission (grant no. SF 2022-2-4035) and the Capital Health Development Project of China grant (grant no. SHF-2016-2-4032). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.