Platelet-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Glaucoma: A Meta-Analysis

Abstract

Aim:

To explore the association between two systemic inflammation markers, platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR), and glaucoma.

Materials & methods:

The authors searched PubMed, Embase and the Cochrane Library for eligible studies comparing PLR and LMR levels in glaucoma patients and healthy controls.

Results:

Analysis revealed that glaucoma patients exhibited significantly elevated PLR levels and reduced LMR compared with nonglaucoma controls. These findings were consistent across various glaucoma types, with the exception of secondary glaucoma, where the association with PLR was less significant.

Conclusion:

The authors found PLR and LMR to be potential valuable biomarkers for glaucoma identification and progression monitoring. These findings highlight the role of systemic inflammation in glaucoma pathogenesis.

Keywords::

• glaucoma
• lymphocyte-to-monocyte ratio
• platelet-to-lymphocyte ratio
• serum markers
• systemic inflammation

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/bmm-2023-0651

Author contributions

Concepts: S-H Chuang, C-H Chang; design: S-H Chuang, C-H Chang; definition of intellectual content: S-H Chuang, C-H Chang; literature search: S-H Chuang, C-H Chang; clinical studies: S-H Chuang, C-H Chang; experimental studies: S-H Chuang, C-H Chang; data acquisition: S-H Chuang, C-H Chang; data analysis: S-H Chuang, C-H Chang; statistical analysis: S-H Chuang, C-H Chang; manuscript preparation: S-H Chuang; manuscript editing: C-H Chang; manuscript review: S-H Chuang, C-H Chang; guarantor: C-H Chang.

Financial disclosure

The authors have no financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.

Competing interests disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.