CYFRA21-1 as a Serum Tumor Marker for Follow-Up Patients with Squamous Cell Lung Carcinoma and Oropharynx Squamous Cell Carcinoma

Abstract

Aim: To evaluate serum soluble fragments of cytokeratin 19 (i.e., CYFRA21-1) as a tumor marker for patients with squamous cell lung carcinoma (SCLC) and oropharynx squamous cell carcinoma (OSCC). Patients & methods: A total of 152 patients with SCLC and OSCC, and 84 control patients were included in the study. CYFRA21-1 concentration was measured using electrochemiluminescence immunoassays. Results: As the disease stages increased, concentrations and sensitivity of CYFRA21-1 increased significantly in patients with SCLC and OSCC. A significant difference in sensitivity between the pretherapeutic group and recurrence group of OSCC (p = 0.001) was observed, as well as for SCLC (p = 0.024). A positive correlation (p = 0.042) existed between CYFRA21-1 concentrations and cancer stage of SCLC and OSCC. There was no significant correlation between CYFRA21-1 concentrations and different organ types with squamous cell cancer (p = 0.51). Conclusion: The CYFRA21-1 assay demonstrated a greater sensitivity for recurrent stages of SCLC and OSCC, and may prove beneficial in the prediction of SCLC and OSCC recurrence at an earlier date.

KEYWORDS::

• cutoff point
• CYFRA21-1
• oropharynx squamous cell carcinoma
• squamous cell lung carcinoma
• tumor marker

Acknowledgements

We are grateful to W Zhang (the First Affiliated Hospital of Harbin Medical University, China) for providing excellent technical assistance.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.