Biomarkers for Helicobacter Pylori Infection and Gastroduodenal Diseases

Abstract

Helicobacter pylori infection is a major cause of gastric cancer. Although identifying H. pylori infected subjects is the first approach for delineating the high-risk population for gastric cancer, the presence of H. pylori antibodies is not sufficient for gastric cancer screening. Among H. pylori infected subjects, only a minority of infected individuals develop gastric cancer. Serologic markers of H. pylori infection can serve as potential predictors for the development of gastric cancer. Serum or urinary H. pylori antibodies, cytotoxin-associated gene A antibodies, pepsinogen and microRNAs were reported to be associated with precancerous lesions or gastric cancer. In this review, we summarized the utilities and limitations of each strategy.

Keywords::

• antibody
• biomarkers
• Helicobacter pylori
• miRNA

Financial & competing interests disclosure

This report is based on work supported in part by grants from the National Institutes of Health (DK62813) (Y Yamaoka), Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan (22390085, 22659087, 24406015 and 24659200) (Y Yamaoka), (23790798) (S Shiota), Strategic Young Researcher Overseas Visits Program for Accelerating Brain Circulation for Japan Society for the Promotion of Science (JSPS), the Strategic Funds for the Promotion of Science and Technology from Japan Science and Technology Agency (JST). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This report is based on work supported in part by grants from the National Institutes of Health (DK62813) (Y Yamaoka), Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan (22390085, 22659087, 24406015 and 24659200) (Y Yamaoka), (23790798) (S Shiota), Strategic Young Researcher Overseas Visits Program for Accelerating Brain Circulation for Japan Society for the Promotion of Science (JSPS), the Strategic Funds for the Promotion of Science and Technology from Japan Science and Technology Agency (JST). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.