Clinicopathological Significance of Notch1 Expression in Cervical Cancer Patients: a Meta-Analysis

Abstract

Aim

Notch1 expression remains incompatible and contradictory with previous findings on cervical cancer. The purpose of this study is to evaluate the association between Notch1 and cervical cancer.

Methods

Available studies were searched from diverse databases and Review Managers 5.3 software was used to perform analysis.

Results

A total of 798 samples were included in this meta-analysis. The Notch1 expression in cancer tissues was higher than that in precancer (p = 0.0003) and normal tissues (p < 0.02). However, the difference of Notch1 expression between cancer cases and precancer cases has no statistical significance (p = 0.35). Moreover, lymph node metastasis (p = 0.02) was associated with higher Notch1 expression in cervical cancer.

Conclusion

Notch1 over-expression indicated aggressive biological behaviors.

Keywords::

• cervical cancer
• clinicopathological parameters
• expression
• meta-analysis
• Notch1

Financial & competing interests disclosure

This study was supported by grants from the National Natural Science Foundation of China (numbers 81160322 and 81460404) and Shihezi University Initiative Research Projects for Senior Fellows (number RCZX201447). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

Additional information

Funding

This study was supported by grants from the National Natural Science Foundation of China (numbers 81160322 and 81460404) and Shihezi University Initiative Research Projects for Senior Fellows (number RCZX201447). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.