Attainment of combined optimal lipid values: a paradigm shift in the management of dyslipidemia

Abstact

Despite the documented benefits of appropriate dyslipidemia management in a multitude of different trial designs, there continues to exist a significant amount of residual cardiovascular risk in both clinical trial and real-world patients even after their LDL-C is controlled. In this article, we explore recent trial data that assess cardiovascular risk reduction associated with high-risk patients when single and multiple lipid fraction targets are attained. Data from these trials demonstrate that more complete control of all-lipid fractions in an individual’s lipid panel may result in additional reductions in cardiovascular risk. Despite these potential benefits, recent analyses show that few patients are being aggressively managed, as demonstrated by the low numbers of patients who are attaining optimal levels of all major lipid parameters. This lack of adequate lipid control presents a potentially significant opportunity to attain increased cardiovascular risk control through improved dyslipidemia management.

Keywords:

• dyslipidemia
• hyperlipidemia
• hypertriglyceriemia
• lipid
• low HDL
• mixed dyslipidemia