Crosstalk Between Prognostic Long Noncoding RNAs and Messenger RNAs As Transcriptional Hallmarks in Gastric Cancer

Abstract

Aim: Our study investigated the significance of the crosstalk between long noncoding RNAs (lncRNAs) and mRNAs in gastric cancer (GC). Methods: lncRNA and mRNA expression profiling data in 671 GC tumors and 77 nontumorous gastric tissues were retrieved from the gene expression omnibus database: GSE54129, GSE13911, GSE19826, GSE79973, GSE15459 and GSE66229. Differentially expressed analysis, RNA coexpression network construction, gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment analyses were conducted in this study. Results: Using differentially expressed and prognostic lncRNAs or mRNAs in GC, we constructed the lncRNA–mRNA coexpression networks. This network involved with vital GO and KEGG pathways. Conclusion: Our study reveals coexpressed lncRNAs and mRNAs as transcriptional hallmarks in GC patients which provide interesting information regarding the incidence and outcome of GC.

Keywords::

• long noncoding RNA
• messenger RNA
• stomach neoplasms

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/epi-2017-0136

Financial & competing interests disclosure

This work was supported by National Natural Science Foundation of China (No. 81401307 and 81702319) and Natural Science Foundation of Guangdong Province (No. 2014A030310033). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.