Abstract
Emerging evidence has demonstrated that regulatory noncoding RNAs (ncRNAs), such as long noncoding RNAs (lncRNAs) and miRNAs, play crucial roles in the initiation and progress of myocardial ischemia-reperfusion injury (MIRI), which is associated with autophagy, apoptosis and necrosis of cardiomyocytes, as well as oxidative stress, inflammation and mitochondrial dysfunction. LncRNAs serve as a precursor or host of miRNAs and directly/indirectly affecting miRNAs via competitive binding or sponge effects. Simultaneously, miRNAs post-transcriptionally regulate the expression of genes by targeting various mRNA sequences due to their imperfect pairing with mRNAs. This review summarizes the potential regulatory role of lncRNA–miRNA–mRNA axes in MIRI and related molecular mechanisms of cardiac disorders, also provides insight into the potential therapies for MIRI-induced diseases.
Author contributors
W Xiong and J Qian focused on conception and design. W Xiong and Y Qu dedicated to collection and analysis of data. W Xiong, Y Qu, H Chen and J Qian contributed in drafting the manuscript. H Chen and J Qian made critical revisions. All the authors approved final version.
Acknowledgments
The authors are grateful to the members of our laboratories for their support and critical revisions of final version.
Financial & competing interests disclosure
This work was supported by the National Natural Science Foundation of China (grant numbers 81860050, 81460044 and 81160035), Yunnan Provincial Science and Technology Department (grant number 2017FE468[-039]), Health Commission of Yunnan Province (grant number 2018NS0126), Program for Innovative Research Team of Kunming Medical University (grant number CXTD201802), and Yunnan Provincial Ten Thousand-Talent Program-Famous Doctor. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.
Ethical conduct of research
The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.
Data sharing statement
The data come from references or websites and do not involve data sharing. The authors thank the scientists for their contributions in this field.