https://orcid.org/0000-0002-7249-5343
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Abstract
Aim: Some clinical and biological characteristics have been described as prognostic factors for clinical conversion into clinically definite multiple sclerosis in radiologically isolated syndrome (RIS) population. The aim of this study was to assess signatures of circulating miRNAs in those patients according to their conversion status after 5 years of follow-up. Patients&methods: OpenArray plates assessing 216 miRNA candidates were run in 15 RIS patients, and their relative abundances were analyzed. Results: A specific profile of deregulated circulating miRNAs (miR-144-3p, miR-448 and miR-653-3p in cerebrospinal fluid and miR-142-3p, miR-338-3p, miR-363-3p, miR-374b-5p, miR-424-5p, miR-483-3p in plasma) differentiated individuals who remained as RIS after 5 years of follow-up. Conclusion: Circulating miRNAs might be used as prognostic biomarkers for RIS patients.
Supplementary data
To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/epi-2020-0172
Author contributions
M Muñoz-San Martín participated in the design and conceptualization of the study, the analysis or interpretation of the data and drafting or revising the manuscript for intellectual content. S Torras participated in the analysis or interpretation of the data. R Robles-Cedeño participated in the design and conceptualization of the study, acquisition of data and revising the manuscript for intellectual content. M Buxó participated in the analysis or interpretation of the data and revision of the manuscript for intellectual content. I Gomez participated in the acquisition of data and the analysis or interpretation of the data. C Matute-Blanch participated in the acquisition of data and the analysis or interpretation of the data and and revision of the manuscript for intellectual content. M Comabella participated in the analysis or interpretation of the data and drafting or revising the manuscript for intellectual content. LM Villar participated in the analysis or interpretation of the data and drafting or revising the manuscript for intellectual content. H Perkal participated in the design and conceptualization of the study and played a major role in the acquisition of data. E Quintana participated in the design and conceptualization of the study, the analysis or interpretation of the data and drafting or revising the manuscript for intellectual content. LI Ramió-Torrentà participated in the design and conceptualization of the study, interpretation of the data, drafting or revising the manuscript for intellectual content and played a major role in acquisition of data.
Acknowledgments
The authors particularly acknowledge the patients and the IDIBGI Biobank (Biobanc IDIBGI, B. 0000872), integrated in the Spanish National Biobank Network, for their collaboration.
Financial&competing interests disclosure
This study was supported by a grant from the Instituto Carlos III – Spanish Government (PI13/01782) and by a grant from Fundación 2000 (2015). M. Muñoz-San Martín was supported by a FI-DGR 2016 from AGAUR. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.
Ethical conduct of research
The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.