Development and Validation of an Oxidative Phosphorylation-Related Gene Signature in Lung Adenocarcinoma

Abstract

Aim: To develop an oxidative phosphorylation (OXPHOS)-related gene signature of lung adenocarcinoma (LUAD). Materials & methods: We split The Cancer Genome Atlas LUAD cohort into a training set and a test set; we used the least absolute shrinkage and selection operator Cox method to structure the OXPHOS-related prognostic signature in the training set and verified in the test set and GSE30219 dataset. Meanwhile, the diagnostic model was constructed using the logistic Cox method. Results: The signature consisted of seven genes (LDHA, CFTR, HSPD1, SNHG3, MAP1LC3C, COX6B2, and TWIST1). LUAD patients were divided into high- and low-risk groups, demonstrating good diagnostic and prognostic capabilities. Conclusion: We developed the first-ever OXPHOS-related signature with both prognostic predictive power and diagnostic efficacy.

Keywords::

• diagnostic signature
• lung adenocarcinoma
• oxidative phosphorylation
• prognostic signature

Financial & competing interests disclosure

This work was supported by The National Natural Science Foundation of China (no. 81660391); the 1·3·5 project for disciplines of excellence–Clinical Research Incubation Project, West China Hospital, Sichuan University (grant 2019HXFH069); the Science and Technology Department of Sichuan Province (grants 2018JY0105 and 2020YJ0283); and the Education Department of Sichuan (grant 18ZA0158). The authors would like to thank Enago (www.enago.cn) for the writing assistance under the sponsored Grant 2020YJ0283 from the Science and Technology Department of Sichuan Province. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This work was supported by The National Natural Science Foundation of China (no. 81660391); the 1·3·5 project for disciplines of excellence–Clinical Research Incubation Project, West China Hospital, Sichuan University (grant 2019HXFH069); the Science and Technology Department of Sichuan Province (grants 2018JY0105 and 2020YJ0283); and the Education Department of Sichuan (grant 18ZA0158). The authors would like to thank Enago (www.enago.cn) for the writing assistance under the sponsored Grant 2020YJ0283 from the Science and Technology Department of Sichuan Province. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Writing assistance was utilized in the production of this manuscript.