Hypoxia-Associated Alternative Splicing Signature in Lung Adenocarcinoma

Abstract

Aim: To establish a signature based on hypoxia-related alternative splicing (AS) events for lung adenocarcinoma. Materials&methods: The least absolute shrinkage and selection operator Cox approach was used to construct a prognostic model. A nomogram that integrates the final AS predictor and stage was created. The network of the key AS events and splicing factors was created. Results: We created a prognostic signature of 11 AS events. Moreover, a nomogram that constitutes the pathological stage and risk was exhibited to be greatly effective in estimating the survival likelihood of lung adenocarcinoma patients. Conclusion: Herein we developed the first-ever signature based on hypoxia-related AS events with both prognostic predictive power and diagnostic efficacy.

Keywords::

• alternative splicing
• hypoxia
• lung adenocarcinoma
• nomogram
• prognosis
• splicing factor
• tumor-infiltrating

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/epi-2020-0399

Author contributions

Z Xu, F Qin and J Wei conceived and designed the experiments, performed the experiments, prepared figures and/or tables and approved the final draft. Y Sun, W Xiang and J Qin performed the experiments, analyzed the data, authored or reviewed drafts of the paper and approved the final draft. L Yuan, K Deng, T Zheng analyzed the data, prepared figures and/or tables and approved the final draft. S Li conceived and designed the experiments, performed the experiments, prepared figures and/or tables and approved the final draft.

Financial & competing interests disclosure

This study was supported by the National Natural Science Foundation of China (no. NSFC81660488) and the Guangxi Natural Science Foundation under grant no. 2017GXNSFAA198123. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This study was supported by the National Natural Science Foundation of China (no. NSFC81660488) and the Guangxi Natural Science Foundation under grant no. 2017GXNSFAA198123. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.