Abstract
Aim: The present study sought to investigate the therapeutic effect of resveratrol on clear cell renal cell carcinoma. Materials & methods: Cell Counting Kit-8 and 5-ethynyl-2′-deoxyuridine assays were used to verify the cell proliferation. Transwell, real-time quantitative transcription PCR, western blot and β-galactosidase staining were used to verify the migration, macrophage polarization and senescence. The tumor inhibitory effect of resveratrol on clear cell renal cell carcinoma was verified in vivo. Results: This study confirmed that resveratrol could affect the stability of CCNB1 mRNA mediated by RBM15 and inhibit the cancer process by inhibiting the expression of EP300/CBP from the perspective of cell senescence. Conclusion: Resveratrol is able to treat clear cell renal cell carcinoma through RBM15-induced cell senescence.
Tweetable abstract
A recent study has shown that resveratrol RBM15 mRNA stability and suppressing cancer cell proliferation, offering a promising therapeutic approach for kidney cancer. #Resveratrol #Kidney Cancer
Supplementary data
To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/epi-2023-0150
Author contributions
Z Chen and C Liu mad substantial contributions to the concept and the design of the manuscript. Z Chen, T Ye and YC to acquisition, analysis and interpretation of the data. All authors have participated to drafting the manuscript, Z Chen and Y Chen revised it critically. All authors read and approved the final version of the manuscript.
Financial disclosure
The authors have no financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Competing interests disclosure
The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the article. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.
Writing disclosure
No writing assistance was utilized in the production of this manuscript.
Ethical conduct of research
This study was approved and supervised by the Ethics Committee of the Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. The specimens were obtained with the consent of the hospital ethics committee and the informed consent of the patient. In addition, the animal experiment of this study was approved by the ethics committee of our hospital, and the 3R principle was adhered to and supervised by the ethics committee throughout the study design. The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.