Cell-free DNA as a Plausible Biomarker of Chronic Kidney Disease

Abstract

Circulating cell-free DNA (cf-DNA) is released from dead and/or apoptotic leukocytes and due to neutrophil extracellular traps contributing to an inflammatory response. Previous clinical studies have reported that the peak concentrations and dynamic changes of cf-DNA may be used as a noninvasive biomarker of worsening kidney function as well as a guide to the management of kidney allograft rejection. We hypothesized that the pattern and dynamic changes of cf-DNA might be a plausible predictive biomarker for patients at risk of chronic kidney disease (CKD), including individuals with type 2 diabetes mellitus, heart failure, cardiovascular disease and established CKD. Along with it, pre- and posthemodialysis levels of serum cf-DNA appear to be a independent predictor for all-cause mortality in patients with end-stage kidney disease.

Plain language summary

What is this article about?

The article focuses a new view on the risk of kidney function worsening and relating complications based on measurements of circulating fragments of DNA (called nucleotides).

What were the results?

The results showed that a measure of circulating fragments of DNA may detect both the risk of occurrence and the progression of chronic kidney disease in certain patient populations.

What do the results of the study mean?

The study indicates that a strategy of single and serial measurements of circulating DNA fragments is likely to be effective for personalized management of patients with chronic kidney disease, including those on dialysis and after kidney transplantation.

Tweetable abstract

Circulating cell-free DNA appears to be a plausible biomarker for risk of chronic kidney disease development and progression.

Graphical abstract

Keywords::

• biomarkers
• cell-free DNA
• chronic kidney disease
• clinical decision-making
• end-stage kidney disease
• kidney allograft rejection
• kidney failure
• kidney injury

The authors equally contributed to the study.

Financial disclosure

The authors have no financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Competing interests disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.