Chromatin Regulators with Tumor Suppressor Properties and their Alterations in Human Cancers

Abstract

Key components of the cell epigenome include DNA CpG methylation profile and chromatin modification patterns. Chromatin regulators act as master controllers of gene transcription in normal cells through regulation of histone modifications and chromatin remodeling. During human cancer pathogenesis, the functions of chromatin regulators are frequently disrupted by genetic mutations and/or epigenetic alterations, causing perturbation of broad or even genome-wide scale gene-expression profiles. Thus, histone-modifying and chromatin-remodeling genes can be taken as critical ‘cancer genes‘. This review summarizes the current knowledge on chromatin regulators with tumor suppressor properties, as well as their aberrant alterations in human cancers.

KEYWORDS::

• chromatin
• chromatin remodeling
• epigenetic
• genetic
• histone modification
• tumor suppressor

Financial & competing interests disclosure

This work is supported by grants from Hong Kong RGC (#474710) and National Natural Science Foundation of China (#81172582). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This work is supported by grants from Hong Kong RGC (#474710) and National Natural Science Foundation of China (#81172582). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.