Acknowledgements
We would like to thank R Jirtle for informal discussions and sharing his insights on epigenetics, hormesis, exercise and agouti mice.
Financial & competing interests disclosure
W Brown was supported in part by the Air Force Office of Scientific Research (AFOSR). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.