Acknowledgements
We would like to thank R Copeland, P Ho, B Thompson and Z Zdraveski for their critical review of this commentary.
Financial & competing interests disclosure
H Keilhack and J Smith are paid employees of and hold stock in Epizyme. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.