Epigenetic Dysregulation in Follicular Lymphoma

Abstract

The adoption of next-generation sequencing technologies has led to a remarkable shift in our understanding of the genetic landscape of follicular lymphoma. While the disease has been synonymous with the t(14;18), the prevalence of alterations in genes that regulate the epigenome has been established as a pivotal hallmark of these lymphomas. Giant strides are being made in unraveling the biological consequences of these alterations in tumorigenesis opening up new opportunities for directed therapies.

Keywords::

• CREBBP
• EP300
• epigenetics
• EZH2
• follicular lymphoma
• histone acetylation
• histone methylation
• KMT2D
• noncoding RNA

Financial & competing interests disclosure

J Fitzgibbon is supported by a Cancer Research UK Programme Grant (15968). S Araf is a recipient of a Cancer Research UK Clinical Research Fellowship. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

J Fitzgibbon is supported by a Cancer Research UK Programme Grant (15968). S Araf is a recipient of a Cancer Research UK Clinical Research Fellowship. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.