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Clinical Trial Protocol

A Randomized double-blind placebo-controlled Crossover Trial of Sodium Nitrate in Patients With Stable Angina INAS

, , , , , , , , , & show all
Pages 617-626 | Received 18 Mar 2016, Accepted 10 May 2016, Published online: 12 Oct 2016
 

Abstract

In an aging western population, a significant number of patients continue to suffer from angina once all revascularization and optimal medical treatment options are exhausted. Under experimental conditions, oral supplementation with inorganic nitrate was shown to exhibit a blood pressure-lowering effect, and has also been shown to promote angiogenesis, improve endothelial dysfunction and mitochondrial efficiency in skeletal muscle. It is unknown whether similar changes occur in cardiac muscle. In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.

Acknowledgements

The authors are very grateful to A Cardy (Scottish Primary Research Network) for her help with recruitment from primary care centers. The authors would also like to thanks V Harries, A Rudd and F Adamson for their assistance with facilitation of study recruitment.

Financial & competing interests disclosure

The study is funded by the Medical Research Council. Edura CT number: 2012-000196-17. Trial Registration: ClinicalTrials.gov NCT02078921. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

The study is funded by the Medical Research Council. Edura CT number: 2012-000196-17. Trial Registration: ClinicalTrials.gov NCT02078921. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

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