The Value of Gamma Glutamyltransferase in Predicting Myocardial Infarction in Patients With Acute Coronary Syndrome

Abstract

Aim: To assess the utility of gamma-glutamyl transferase (GGT) and C-reactive protein (CRP) in predicting troponin elevation in patients with acute coronary syndrome. Patients: The total of 119 patients were divided into troponin-positive (n = 61) and troponin-negative (n = 58) patients. Results: CRP cut-off value ≥13.4 mg/l had the sensitivity of 68.1% and specificity of 62.5%, while the GGT cut-off value ≥61.5 IU/l had the sensitivity of 66.0% and specificity of 62.0% and combined use of both CRP and GGT had 71.4% sensitivity and 69.6% specificity in predicting troponin increase in acute coronary syndrome patients. Conclusion: GGT might be used as an adjuvant marker for risk assessment patients who present with chest pain and are suspected to have acute coronary syndrome.

Keywords: :

• acute coronary syndrome
• biomarker
• C-reactive protein
• cardiovascular disease
• gamma glutamyltransferase
• myocardial infarction
• receiver operating characteristic
• sensitivity
• specificity
• subclinical inflammation
• troponin

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

Approval for the study was obtained by the local Ethics Committee. All procedures on human subjects were performed in accordance with the Helsinki Declaration of 1975. All subjects included in the study signed informed consent upon careful explanation of the study procedure.