Role of Lysosomes in HSV-Induced Pathogenesis

Abstract

HSV can evade host defenses and cause lifelong infection and severe illness. Lysosomes are catabolic organelles that play an important role in the regulation of cellular homeostasis. Lysosomal dysfunction and alterations in the process of autophagy have been identified in a variety of diseases, including HSV infection, and targeting lysosomes is a potential anti-HSV therapeutic strategy. This article reviews the role of lysosomes and lysosome-associated proteins in HSV infection, providing attractive targets and novel strategies for the treatment of HSV infection.

Tweetable abstract

Lysosomes play an important role in the regulation of cellular homeostasis, and targeting lysosomes is a potential anti-HSV therapeutic strategy. This article takes a look at the role of lysosomes and lysosome-associated proteins in HSV infection.

Keywords::

• autophagy
• HSV
• hydrolases
• lysosome-associated membrane glycoproteins
• lysosome

Author contributions

J Ding wrote the manuscript. L Ding conceived the work and revised the manuscript. Both authors read and approved the final manuscript.

Financial & competing interests disclosure

This work was supported by the Initial Scientific Research Fund of PhD in Hubei University of Science and Technology (BK202120). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This work was supported by the Initial Scientific Research Fund of PhD in Hubei University of Science and Technology (BK202120). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.