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Abstract
Candidiasis is a significant cause of invasive human mycosis with associated mortality rates that are equivalent to, or worse than, those cited for most cases of bacterial septicemia. As a result, considerable efforts are being made to understand how the fungus invades host cells and to identify new targets for fungal chemotherapy. This has led to an increasing interest in Candida glycobiology, with an emphasis on the identification of enzymes essential for glycoprotein and adhesion metabolism, and the role of N- and O-linked glycans in host recognition and virulence. Here, we refer to studies dealing with the identification and characterization of enzymes such as dolichol phosphate mannose synthase, dolichol phosphate glucose synthase and processing glycosidases and synthesis, structure and recognition of mannans and discuss recent findings in the context of Candida albicans pathogenesis.
Acknowledgements
The authors are indebted to Claudia Iris Robledo-Ortiz for her valuable help with the figures, and other people, mostly students, who directly or indirectly contributed to the work presented in this review.
Financial & competing interests disclosure
Research in the laboratories of Patricia Ponce-Noyola, Arturo Flores-Carreón and Everardo López-Romero was jointly supported by grants Nos. 2005-C0-11919, 83414, 458100-5-0041PN from CONACyT, México, and 39528-Q from SEP-CONACyT, México. Research in the laboratory of Neil AR Gow and Héctor M Mora-Montes was supported by grant No. 080088 from The Wellcome Trust, London, UK.