Association of the miR-146a Rs2910164 Polymorphism with Gastric Cancer Susceptibility and Prognosis

ABSTRACT

Aim: Single nucleotide polymorphisms in miRNA-coding region may be involved in the development or progression of gastric cancer (GC). Materials & methods: Six SNPs (miR-146a rs2910164, miR-196a2 rs11614913, miR-27a rs895819, miR-423 rs6505162, miR-608 rs4919510, miR-149 rs2292832) were genotyped in 898 histologically confirmed GC cases and 992 controls in this hospital-based case–control study. Results: The G/G genotype of rs2910164 was associated with reduced risk of GC (odds ratio: 0.76, 95% CI: 0.60–0.97; p = 0.024). Meanwhile, in 838 GC cases receiving radical tumorectomy, cases bearing the G/G genotype of rs2910164 had shorter survival time comparing to cases with C/C or C/G genotype (hazard ratio: 1.36, 95% CI: 1.04–1.78, p = 0.023). Conclusion: rs2910164 of miR-146a is associated with GC.

KEYWORDS:

• gastric cancer
• miRNA
• overall survival
• polymorphism
• susceptibility

Supplementary data

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Financial & competing interests disclosure

This work was supported by National Natural Science Foundation of China (No. 81373084 and 81273065), the Scientific and Technological Development Program of Jilin Province (No. 20150414014GH and 20160519016JH) and the Norman Bethune Program of Jilin University (No. 2013025). The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.