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Abstract
Aim: To characterize the clinical indications of females (<15 years old) undergoing ovarian tissue cryopreservation (OTC) through the Oncofertility Consortium’s National Physicians Cooperative (OC-NPC). Patients & methods: The clinical indications of 114 females who underwent OTC were classified, and their incidence was compared with childhood cancer databases. Results: Leukemias/myeloproliferative diseases/myelodysplastic diseases and hemoglobinopathies were the most prevalent oncologic and nononcologic indications for OTC, respectively. The frequencies of malignant bone tumors and soft tissue and other extraosseous sarcomas were higher in the OC-NPC cohort relative to the general population, while CNS/intracranial/intraspinal neoplasms, retinoblastoma and hepatic tumors were lower. Conclusion: Those opting for OTC through the OC-NPC are at highest fertility risk, indicating that the appropriate patient populations are being identified.
Acknowledgements
The authors would like to thank the Oncofertility Consortium’s National Physicians Cooperative participants and sites, the Oncofertility Consortium, and the University of Kansas Medical Center.
Financial & competing interests disclosure
This work was supported by the Center for Reproductive Health After Disease (P50 HD076188–02) from the National Centers for Translational Research in Reproduction and Infertility (NCTRI). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.