Comparison of Three Prognostic Models for Predicting Cancer-Specific Survival among Patients with Gastrointestinal Stromal Tumors

Abstract

Aim: To evaluate the predictive value for cancer-specific survival of the models of the American Joint Committee on Cancer (AJCC) stage, NIH and Armed Forces Institute of Pathology (AFIP) among patients with gastrointestinal stromal tumors (GISTs). Methods: Surveillance, Epidemiology and End Results database (2010–2014) was accessed. Overall survival analysis and adjusted cancer-specific Cox regression hazard was calculated. Results: For gastric GISTs, concordance-index according to AJCC was 0.834; according to NIH was 0.833; according to AFIP was 0.836. Concordance-index for nongastric GISTs according to AJCC was 0.800, according to NIH was 0.801 and according to AFIP was 0.799. Conclusion: The performance of the three models is comparable with regards to cancer-specific survival prediction.

Keywords::

• AFIP
• AJCC
• GIST
• NIH
• SEER

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.