Lactic Dehydrogenase to Albumin Ratio in Prediction of Unresectable Pancreatic Cancer with Intervention Chemotherapy

Abstract

Aim: To validate the prognostic value of lactic dehydrogenase to albumin ratio (LAR) in patients with unresectable pancreatic cancer treated by intervention chemotherapy. Materials & methods: There were 139 patients retrospectively analyzed in this study. The survival was depicted with Kaplan–Meier curves and calculated by log-rank test. We used Cox proportional hazards regression model with univariate and multivariate analyses, and integrated all independent risk factors to establish the nomogram. Results: Patient with higher LAR group had poorer overall survival (OS). The Tumor, Node, Metastasis stage, carcinoembryonic antigen and LAR have been shown to be independent prognostic indicators for OS. The nomogram indicated superior predictive accuracy for OS. Conclusion: The preoperative LAR can be a prognostic indicator for unresectable pancreatic cancer patients with interventional therapy.

Keywords::

• lactic dehydrogenase to albumin ratio
• nomogram
• prognosis
• unresectable pancreatic cancer

Financial & competing interests disclosure

This study was funded by the Youth Project of National Natural Foundation of China (81201170) and Shanghai Municipal Commission of Health and Family Planning (20160277). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

This study was approved by the Ethics Committee of Zhongshan Hospital.

Additional information

Funding

This study was funded by the Youth Project of National Natural Foundation of China (81201170) and Shanghai Municipal Commission of Health and Family Planning (20160277). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.