The Prognostic Analysis of Different Metastatic Patterns Extensive-Stage Small-Cell Lung Cancer Patients: A Large Population-Based Study

Abstract

Aim: To analyze the metastasis patterns and prognosis differences for extensive-stage small-cell lung cancer patients. Methods: Log-rank tests were used to calculate and compare survival estimates. Cox regression analyses were used to evaluate the prognosis factors. Results: The liver was the most common metastatic site, and lung was the least common. In two metastatic sites, liver and bone metastases were the most common combination of sites. An isolated liver metastasis had the worst overall survival (OS) and cancer-specific survival (CSS) among metastatic sites (both p < 0.001). Liver and lung metastases were associated with worse CSS (p < 0.039) and OS (p < 0.015). However, for patients with three metastatic sites showed no statistical differences in their CSS and OS (all, p > 0.05). Conclusion: Extensive-stage small-cell lung cancer patients with metastasis to the liver alone or in combination with other organs appear to have worse outcomes.

Keywords::

• metastasis pattern
• prognosis
• SEER
• small-cell lung cancer

Financial & competing interests disclosure

This study was supported by the Special Fund for National Health and Family Planning Commission: specification and application of image-guided individualized radiotherapy in non-small-cell lung cancer (Grant No. 201402011) and the National natural Science Foundation of China (No. 81603348). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

Additional information

Funding

This study was supported by the Special Fund for National Health and Family Planning Commission: specification and application of image-guided individualized radiotherapy in non-small-cell lung cancer (Grant No. 201402011) and the National natural Science Foundation of China (No. 81603348). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.