Association of Five Genetic Variations in DNMT1 and DNMT3A with Gastric Cancer in a Chinese Population

Abstract

Aim: To determine whether genetic variations in DNMT1 and DNMT3A could be associated with gastric cancer risk. Materials & methods: A total of 466 patients and 452 healthy controls were enrolled in this study. Genotypes were examined by using the Sequenom MassARRAY platform. Results: No significant differences in the distribution frequencies were observed between the groups. However, subgroup analysis revealed that, in the group aged ≤60 years, DNMT3A rs13420827 was associated with reduced gastric cancer risk, and that carrier of GC/GG genotype was associated with reduced risk of gastric cancer with low differentiation or at the T3–T4 stage. Conclusion: This study suggests that five genetic variations of interest in DNMT1 and DNMT3A are not associated with the presence of gastric cancer, but that rs13420827 may contribute to the gastric cancer risk for those younger individuals, the risk of which may be influenced by the characteristics of tumor.

Keywords::

• DNMT1
• DNMT3A
• gastric cancer
• genetic variation

Supplementary data

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Acknowledgements

The authors are grateful to H-G Xie, General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China, for his critical review, scientific editing and constructive comments.

Financial & competing interests disclosure

This study was supported by the Natural Science Foundation of China (81670570, 81700572), the Key Research and Development Program of Jiangsu Province (BE2016789), and Science and Technology Development Fund of Nanjing Medical University (2017NJMUZD097). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This study was supported by the Natural Science Foundation of China (81670570, 81700572), the Key Research and Development Program of Jiangsu Province (BE2016789), and Science and Technology Development Fund of Nanjing Medical University (2017NJMUZD097). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.