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Abstract
Aim: To analyze the prognostic factors and the impact of postoperative radiotherapy (PORT) in parotid gland infiltrating ductal carcinoma (IDC). Materials&methods: 252 patients diagnosed with parotid gland IDC were identified from the SEER database. Kaplan–Meier and Cox regression analysis was performed to evaluate the prognostic factors. Propensity score matching was applied then. Results: Multivariate analysis showed old age and chemotherapy were independent risk factors in parotid gland IDC. Subgroup analysis demonstrated that overall survival (OS) rate of the PORT group was significantly superior to that of the no radiotherapy group in the T3–4 subgroup (p = 0.049), N1 subgroup (p = 0.019) and Tumor, Node, Metastasis (TNM) III subgroup (p = 0.025). Conclusion: PORT improved survival of parotid gland IDC patients within T3–4, N1 and TNM III subgroups.
Acknowledgements
We thank M Zhou for his guidance in statistics.
Authors' contributions
All authors contributed to the research of data, the discussion of content and the revision of the manuscript. T Lv and Y Wang contributed significantly to the writing of the original submission.
Financial&competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.
Ethical conduct of research
The informed consent was not needed because personal identifying information was not involved in SEER database.