Comparison of Different Prognostic Models for Predicting Cancer-Specific Survival in Bladder Transitional Cell Carcinoma

Abstract

Objective: To construct the newly valuable nomogram which can compare the predictive performance with American Joint Committee on Cancer (AJCC) staging system in bladder transitional cell carcinoma (BTCC). Methods: BTCC patients were screened (2004–2015) from the SEER database. The nomogram incorporating lymph node ratio was constructed to evaluate individualized cancer-specific survival. Results: The C-index of the nomogram for predicting cancer-specific survival was 0.743 (95% CI: 0.720–0.766), which was higher than C-index of the AJCC staging system. Conclusion: Lymph node ratio can be a reliable prognostic indicator for BTCC. The proposed nomogram showed more satisfactory predictive accuracy and wider applicability than current AJCC staging system in individualized prediction of BTCC patients.

Keywords::

• bladder transitional cell carcinoma
• BTCC
• cancer-specific survival
• LNR
• lymph node ratio
• nomogram

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: https://www.tandfonline.com/doi/suppl/10.2217/fon-2018-0695

Acknowledgements

The authors gratefully acknowledge the SEER database (established by the National Cancer Institute, USA), which made the data of BTCC available. Also, Huang Chuiguo wants to thank the care and support from Yuan Naijun. Will you spend your rest of time with me?

Financial&competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Therefore, no ethics approval was sought for this study by authors as data used were the National Cancer Institute’s SEER database, which is a publicly available de-identified population-based database. We obtained permission to access SEER dataset with the reference number 12534-Nov2017.