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Future Oncology Volume 15, 2019 - Issue 35
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Research Article

Analysis of TGCA Data Reveals Genetic and Epigenetic Changes and Biological Function of MUC Family Genes in Colorectal Cancer

Zhipeng Jiang1 Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, 26 Yuancunerheng Road, Guangzhou510655, Guangdong, PR China;2 Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal & Pelvic Floor Diseases, Supported by National Key Clinical Discipline, Guangzhou510655, Guangdong, PR China
,
Huashe Wang1 Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, 26 Yuancunerheng Road, Guangzhou510655, Guangdong, PR China;2 Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal & Pelvic Floor Diseases, Supported by National Key Clinical Discipline, Guangzhou510655, Guangdong, PR China
,
Liang Li1 Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, 26 Yuancunerheng Road, Guangzhou510655, Guangdong, PR China
,
Zehui Hou1 Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, 26 Yuancunerheng Road, Guangzhou510655, Guangdong, PR China;2 Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal & Pelvic Floor Diseases, Supported by National Key Clinical Discipline, Guangzhou510655, Guangdong, PR China
,
Wei Liu1 Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, 26 Yuancunerheng Road, Guangzhou510655, Guangdong, PR China;2 Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal & Pelvic Floor Diseases, Supported by National Key Clinical Discipline, Guangzhou510655, Guangdong, PR China
,
Taicheng Zhou1 Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, 26 Yuancunerheng Road, Guangzhou510655, Guangdong, PR China;2 Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal & Pelvic Floor Diseases, Supported by National Key Clinical Discipline, Guangzhou510655, Guangdong, PR China
,
Yingru Li1 Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, 26 Yuancunerheng Road, Guangzhou510655, Guangdong, PR China;2 Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal & Pelvic Floor Diseases, Supported by National Key Clinical Discipline, Guangzhou510655, Guangdong, PR China
&
Shuang Chen1 Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, 26 Yuancunerheng Road, Guangzhou510655, Guangdong, PR China;2 Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal & Pelvic Floor Diseases, Supported by National Key Clinical Discipline, Guangzhou510655, Guangdong, PR ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3299-2860
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Pages 4031-4043 | Received 25 Jun 2019, Accepted 18 Oct 2019, Published online: 27 Nov 2019
 
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Abstract

Aim: Few studies focused on functions and regulatory networks of MUC family members in colorectal cancer based on comprehensive analysis of online database. Materials & methods: Copy number variation, methylation, pathway analysis and drug influence on MUC expression were analyzed based on The Cancer Genome Atlas and GTEx database. Results: Copy number variation analysis showed MUC heterozygous amplification and heterozygous deletion predominate. Methylation of MUC17, MUC12 and MUC4 were found related to gene expression. Function of MUC family genes mainly affects pathways such as apoptosis, cell cycle, DNA damage and EMT pathways. PLX4720, dabrafenib, gefitinib, afatinib and austocystin D can alter the expression of MUC gene. Conclusion: The genetic and epigenetic changes of MUC are related to the level of MUC expression in colorectal cancer.

Author contributions

Z Jiang designed the study protocol and the main writers of manuscript, H Wang, L Li, Z Hou and W Liu, collected the data from databases. T Zhou and Y Li finished the bioinformatics analysis. S Chen was a guarantor of integrity of the entire study. All authors read and approved the final manuscript.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that no human or animal experiments were adopted in this study.

Data sharing statement

All data were presented in the manuscript.

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