Systemic Immune-Inflammation Index Predicted Overall Survival and Radiosensitivity in Advanced Non-Small-Cell Lung Cancer

Abstract

Aim: To evaluate the predictive significance of systemic immune-inflammation index (SII) on overall survival (OS) and radiosensitivity in advanced non-small-cell lung cancer. Materials & methods: Kaplan–Meier analysis and Cox proportional hazard models were used to assess the prognostic value of SII. Results: The optimal cutoff for SII was 555.59, with an area under the curve of 0.782 (sensitivity: 76.6%, specificity: 71.9%, 95% CI: 0.730–0.833), respectively. Median OS (p < 0.001) in the low SII group (32.8 months) was better than the OS in the high SII group (8.5 months). SII-low group statistically exhibited a better radiosensitivity. Conclusion: SII was an independent prognostic factor for OS and predictive factor for radiosensitivity. Higher level of SII associated with poorer OS and poorer radiosensitivity.

Keywords::

• non-small-cell lung cancer
• overall survival
• radiosensitivity
• systemic immune-inflammation index

Author contributions

X Li contributed to data collection and manuscript writing. P Hu designed the study. J Zhang and J Liu contributed to statistic analysis. The authors certify that no individuals other than the listed coauthors contributed to this publication.

Financial & competing interests disclosure

This work was supported by the National Natural Science Foundation of China (grant no. 81672974 and no. 81602719) and Science and Technology Development Plan of Shandong Province (no. 2017GSF18111). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained Shandong Provincial Qianfoshan Hospital (The First Affiliated Hospital of Shandong First Medical University) review board (no. S017) review board approval. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (grant no. 81672974 and no. 81602719) and Science and Technology Development Plan of Shandong Province (no. 2017GSF18111). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.