The Effects of Herpes Virus Glycoprotein Glycosylation On Viral Infection and Pathogenesis

Abstract

Herpes virus is an enveloped virus with many glycoproteins essential for viral infection and immune evasion. Several glycosylation sites exist on the glycoproteins of herpes viruses, including N- and O-glycosylation sites. Glycosylation affects herpes virus infection and pathogenesis in different ways, including the attachment and entry of the herpes virus into host cells, virus replication and the host’s immune function. This article summarized the current knowledge on the glycosylation of herpes virus envelope glycoproteins and its impact on viral infection and demonstrated several applications of glycosylation inhibitors.

Keywords:

• Epstein–Barr virus
• glycosylation
• herpes simplex virus
• herpes virus
• human cytomegalovirus

Author contributions

Y Chen: writing – original draft preparation. W Liu and B Luo: writing – review and editing. All authors have read and agreed to the published version of the manuscript.

Acknowledgments

The authors give their thanks to everyone who helped with this article.

Financial & competing interests disclosure

This work was supported by the Natural Science Foundation of Shandong Province, China (ZR2020MH302 and ZR2021MC068). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.