Col10A1 is a Potential Immunotherapy Biomarker Associated With Immune Infiltration and Deficient Mismatch Repair in Colon Cancer

Abstract

Aim: Our study aimed to identify the role of COL10A1 in colon cancer, including interaction with immune infiltrates and somatic mutations. Methods: COL10A1 expression and prognostic value were assessed. Correlations between COL10A1 and various immune parameters were conducted by bioinformatic analysis. Results: Our study demonstrated that COL10A1 is overexpressed in colon cancer and correlates with poor patient survival. The expression level of COL10A1 is significantly associated with mismatch repair deficiency and immune infiltration. High expression of COL10A1 may confer greater sensitivity to anti-PD-1 treatment in colon cancer patients. Conclusion: COL10A1 is a potential diagnostic biomarker associated with deficient mismatch repair and immune infiltration in colon cancer.

Plain language summary

Colorectal cancer (CRC) is a deadly disease and we do not have a cure. Immunotherapy is a new method that can help CRC patients to live longer, but it only works for some people. To find out who will get good results with immunotherapy, we looked at a protein named COL10A1. We found more COL10A1 in colon cancer tissues than in healthy tissues. CRC patients with a lot of COL10A1 are more likely to die than those patients with low levels of this protein. COL10A1 can interact with some immune cells and by looking at how much COL10A1 is in different CRC patients, we may be able to choose the right patients to treat with immunotherapy.

Keywords::

• COL10A1
• colon cancer
• immune infiltration
• immunotherapy
• mismatch repair deficiency

Author contributions

Conceptualization: Q Wu and S Cai; immunohistochemistry staining: S Cai and ZW Sun; software and data analysis: S Cai, ZW Sun, Y Yan and WF Li; writing (original draft, preparation): S Cai and ZW Sun; writing (review and editing): Q Wu, S Cai, ZW Sun, Y Yan and WF Li.

Acknowledgments

The authors would like to thank Peking University Cancer Hospital for the support to this research. The authors also sincerely thank Dongfeng Niu and Jing Zhao for their great support to the immunohistochemistry score.

Financial & competing interests disclosure

The current study was supported by Science Foundation of Peking University Cancer Hospital (2021-22). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

The current study was supported by Science Foundation of Peking University Cancer Hospital (2021-22). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.