An Update on the Use of Immunoglobulin for the Treatment of Immunodeficiency Disorders

Abstract

For patients with significant antibody deficiencies, immunoglobulin therapy is the mainstay of treatment as it significantly reduces both the frequency and severity of infections. The formulations and delivery methods of immunoglobulin have evolved over time, and continued improvements have allowed for increased access to this effective medication. This review is an update on the current status of immunoglobulin therapy in immunodeficiency disorders, and discusses the mechanisms, forms and dosing, and indications for immunoglobulin replacement.

Keywords::

• antibody deficiency
• immunoglobulin replacement
• intravenous immunoglobulin
• mechanisms of immunoglobulin
• primary immunodeficiency
• subcutaneous immunoglobulin

Financial & competing interests disclosure

C Cunningham-Rundles is partially supported by grants from the NIH (AI-1061093, AI-0860037, AI-1048693) and the David S Gottesman Immunology Chair. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

C Cunningham-Rundles is partially supported by grants from the NIH (AI-1061093, AI-0860037, AI-1048693) and the David S Gottesman Immunology Chair. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.