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Research Article

Promising Therapeutic Effect of Gold Nanoparticles Against Dinitrobenzene Sulfonic Acid-Induced Colitis in Rats

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Pages 1657-1679 | Received 10 Jan 2018, Accepted 24 Apr 2018, Published online: 07 Aug 2018
 

Abstract

Aim: The aim of this study is to evaluate the therapeutic effect of two different doses of naked gold nanoparticles (AuNPs) in the experimental colitis in rats. Materials & methods: Colitis was induced in rats by single intracolonic instillation of dinitro-benzene sulfonic acid (250 μl DNBS-25 mg/rat). 4 days later the rats were intravenously injected with a single dose of AuNPs 40 and 400 μg/kg of size 16–25 nm. Results: In comparison with dinitro-benzene sulfonic acid-colitis group, the exposure to AuNPs for 72 h ameliorated the liver and kidney functions, increased the regenerative capacity of damaged colon tissues, suppressed the inflammatory cytokine response and diminished the colonic malondialdehyde and myeloperoxidase activities. In addition, there was a remarkable improvement in the antioxidant defense system. Conclusion: Our study suggested a new therapy for experimental colitis without noticeable drawbacks.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Ethical disclosure

The experiments were performed in accordance with the research protocols established by Institutional Animal Care and Use Committee. All the experimental procedures were done following the international guidelines, Guide for Care and Use of Laboratory Animals.

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