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Abstract
Aim: The present study was designed to probe the cardioprotective effects of nanoyttria (NY). Materials & methods: NY was characterized using various techniques. Isoproterenol (ISO)-induced cardiotoxicity challenged mice were treated with NY for 28 days at two doses (0.4 and 4 mg/kg, intraperitoneally). Results: NY demonstrated free radical scavenging activity as shown by a 2,2-diphenyl-1-picrylhydrazyl assay. NY treatment showed alleviation of ISO-induced cardiotoxicity as evident from the reduction in biochemical parameters. The expression of proinflammatory cytokines (IL-1β, IL-6 and TNF-α) showed significant decrease upon NY treatment. Histopathology and ECG showed protection in histoarchitecture and rhythm of heart, respectively. Reduction in hydroxyproline and TGF-β1 expression indicated antifibrotic activity. Conclusion: We report for the first time that NY ameliorates ISO-induced cardiac remodeling.
Acknowledgments
The authors are thankful to Kannan Govindaraj (University of Twente, The Netherlands), Swarna Bale, Sapana Bansod and Gauthami Pulivendala for the generous support in proofreading the manuscript for grammatical errors.
Financial & competing interests disclosure
The authors received financial support from the Director, NIPER Hyderabad and Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India. C Godugu received financial support from the Department of Biotechnology (DBT), Govt. of India via North East-Twinning Grant: MAP/2015/58, Indo-Brazil Grant: DBT/IC-2/Indo-Brazil/2016-19/01 and DST-Science and Engineering Board-Early Career Research Award (SERB-ECR) Grant: ECR/2016/000007. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.
Ethical conduct of research
The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.