Nanotechnology-Based Mucoadhesive and Mucus-Penetrating Drug-Delivery Systems for Transbuccal Drug Delivery

Abstract

Buccal drug-delivery systems present a promising approach for the drug delivery to the buccal mucosa, addressing oral cavity-specific problems, enabling systemic delivery and minimizing adverse effects on biological systems. Numerous strategies have been proposed to load drug-containing nanoparticles (NPs) to the buccal mucosa for local and systemic applications. There has been considerable interest in the development of mucoadhesive buccal formulations, particularly hydrogel composites utilizing mucoadhesive films incorporating NPs. Drug permeability and controlled drug release through buccal drug delivery continues to pose a challenge despite the availability of various remedies. This review highlights the need for, mechanisms and latest advances in NP-based transbuccal drug delivery with a focus on various pathological disorders and examples and limitations of the different methods.

Keywords::

• buccal drug delivery
• mucoadhesive
• nanoparticle-hydrogel composite
• nanoparticles
• transbuccal

Financial & competing interests disclosure

The authors have no financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

The authors have no financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript.