Lipid Nanoparticles for the Topical Delivery of Retinoids and Derivatives

Abstract

Retinoids are lipophilic compounds that are highly used in cosmetics/therapeutics for skin disorders. Conventional formulations are limited by poor water solubility, high chemical/photochemical instability and the irritation of retinoids. Interestingly, lipid nanoparticles enable the administration of retinoids in aqueous media, providing drug stabilization and controlled release. Recently, it has been demonstrated that retinoids in solid lipid nanoparticles, nanostructured lipid carriers, nanoemulsions and nanocapsules can decrease degradation, improve targeting and enhance efficacy for the treatment of skin disorders. This article focuses on the formulation, fabrication, characterization and in vitro/in vivo evaluation of solid lipid nanoparticles, nanostructured lipid carriers, nanoemulsions and nanocapsules loaded with retinoids for skin administration. Furthermore, the incorporation of these lipid nanoparticles into secondary vehicles is discussed.

Keywords::

• hydrogels
• lipid nanosystems
• nanocapsules
• nanoemulsions
• nanostructured lipid carriers
• retinoids
• skin delivery
• solid lipid nanoparticles
• topical delivery

Financial & competing interests disclosure

F Oyarzun-Ampuero, JO Morales and J Morales acknowledges funding from Fondecyt 11121481, 11130235 and 11121172, respectively. K Valdés acknowledges funding form Conicyt 791100023. All authors acknowledge funding from Fondap 15130011. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

F Oyarzun-Ampuero, JO Morales and J Morales acknowledges funding from Fondecyt 11121481, 11130235 and 11121172, respectively. K Valdés acknowledges funding form Conicyt 791100023. All authors acknowledge funding from Fondap 15130011. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.