Tumor-Targeting Glycol Chitosan Nanoparticles as A Platform Delivery Carrier in Cancer Diagnosis and Therapy

Abstract

A natural based polymer, chitosan has received widespread attention in drug delivery systems due to its valuable physicochemical and biological characteristics. In particular, hydrophobic moiety-conjugated glycol chitosan can form amphiphilic self-assembled glycol chitosan nanoparticles (GCNPs) and simultaneously encapsulate hydrophobic drug molecules inside their hydrophobic core. This GCNP-based drug delivery systems exhibit excellent tumor-homing efficacy, attributed to the long blood circulation and the enhanced permeability and retention effect; this tumor-targeting drug delivery results in improved therapeutic efficiency. In this review, we describe the requisite properties of GCNPs for cancer therapy as well as imaging for diagnosis, such as their basic characteristics, in vitro delivery efficiency and in vivo tumor-targeting ability.

Keywords::

• amphiphilic nanoparticles
• cancer therapy
• diagnosis
• EPR
• glycol chitosan

Financial & competing interests disclosure

This study was funded by GiRC and GRL program (2012K1A1A2A01056095, 2013K1A1A2A02050115) through the National Research Foundation of Korea (NRF) and the Intramural Research Program of KIST. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This study was funded by GiRC and GRL program (2012K1A1A2A01056095, 2013K1A1A2A02050115) through the National Research Foundation of Korea (NRF) and the Intramural Research Program of KIST. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.