Antibody-Targeted Biodegradable Nanoparticles for Cancer Therapy

Abstract

The use of nanotechnology has great potentials to revolutionize the future cancer diagnosis and therapy. In this context, various nanoparticles (NPs) have been developed for targeted delivery of diagnostic/therapeutic agents to the tumor sites, which thus result in greater efficacy and much less side effects. The targeting property of NPs is often achieved by functionalizing their surface with tumor-specific ligands, such as antibodies, peptides, small molecules and oligonucleotides. In this review, we will discuss recent progress in the multifunctional design of antibody-targeted NPs with a special focus on liposomal, polymeric and protein-based delivery systems.

Keywords::

• antibody conjugation
• cancer therapy
• multifunctional nanoparticles
• nanomedicines
• targeted delivery

Financial & competing interests disclosure

This work was supported by the School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This work was supported by the School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.