Clinical and Genetic Predictors of Dipeptidyl Peptidase-4 Inhibitor Treatment Response in Type 2 Diabetes Mellitus

Abstract

Aim: To determine the clinical and genetic predictors of the dipeptidyl peptidase-4 (DPP-4) inhibitor treatment response in Type 2 diabetes mellitus (T2DM) patients. Patients & methods:DPP4, WFS1 and KCNJ11 gene polymorphisms were genotyped in a cohort study of 662 T2DM patients treated with DPP-4 inhibitors sitagliptin, vildagliptin or linagliptin. Genotyping was performed by Applied Biosystems TaqMan SNP genotyping assay. Results: Patients with triglyceride levels less than 1.7 mmol/l (odds ratio [OR]: 2.2.; 95% CI: 1.031–4.723), diastolic blood pressure (DBP) less than 90 mmHg (OR: 1.7; 95% CI: 1.009–2.892) and KCNJ11 rs2285676 (genotype CC) (OR: 2.0; 95% CI: 1.025–3.767) were more likely to response to DPP-4 inhibitor treatment compared with other patients, as measured by HbA1c levels. Conclusion: Triglycerides, DBP and KCNJ11 rs2285676 are predictors of the DPP-4 inhibitor treatment response in T2DM patients.

Keywords::

• DPP4
• dipeptidyl peptidase-4 inhibitors
• HbA1c
• KCNJ11
• Type 2 diabetes mellitus
• WFS1

Financial & competing interests disclosure

This article was funded by the Ministry of Science, Technology and Innovation, Malaysia (Sciencefund: 12-02-03-2097); University of Malaya, Malaysia (University of Malaya Research Programme: RP024A-14HTM); and Postgraduate Research Grant: PG011-2012B. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

Additional information

Funding

This article was funded by the Ministry of Science, Technology and Innovation, Malaysia (Sciencefund: 12-02-03-2097); University of Malaya, Malaysia (University of Malaya Research Programme: RP024A-14HTM); and Postgraduate Research Grant: PG011-2012B. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.