A Model to Assess the Cost–Effectiveness of Pharmacogenomics Tests in Chronic Heart Failure: The Case of Ivabradine

Abstract

Pharmacogenomics (PGx) tests have the potential of improving the effectiveness of expensive new drugs by predicting the likelihood, for a particular patient, to respond to a treatment. The objective of this study was to develop a pharmacoeconomic model to determine the characteristics and the cost–effectiveness of a hypothetical PGx test, which would identify patients who are most likely to respond to an expensive treatment for chronic heart failure. For this purpose, we chose the example of ivabradine. Our results suggest that the use of a PGx test that could select a subgroup of patients to be treated with an expensive drug has the potential to provide more efficient drug utilization.

Keywords::

• cardiovascular diseases
• chronic heart failure
• cost%ndash;effectiveness
• Markov model
• New York Heart Association
• pharmacogenomics tests
• quality-adjusted life years

To view the supplementary data that accompany this paper,please visit the journal website at:www.futuremedicine.com/doi/full/10.2217/pgs-2016-0054

Financial & competing interests disclosure

This work was supported by funds from Genome Canada and Genome Québec for the project: Personalized medicine strategies for molecular diagnostics and targeted therapeutics of cardiovascular diseases. J-C Tardif has received research grants and honoraria from Servier. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This work was supported by funds from Genome Canada and Genome Québec for the project: Personalized medicine strategies for molecular diagnostics and targeted therapeutics of cardiovascular diseases. J-C Tardif has received research grants and honoraria from Servier. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.