CYP2D6 and CYP2C19 Genotyping in Psychiatric Patients on Psychotropic Medication in the Former Dutch Antilles

Abstract

Aim: This study was aimed to asses the prevalence of CYP2D6 and CYP2C19 polymorphisms in psychiatric patients and in volunteers from Dutch caribbean origin. Methods: In total, 435 individuals were genotyped for CYP2D6 and CYP2C19. Of these, 269 were psychiatric patients on psychotropic medication, living in Curaçao and 166 were volunteers from the Dutch Caribbean population. Results: No differences in prevalence of alleles were found. Conclusion: Although prevalence of alleles appeared to be very different from African and Caucasian populations, the distribution into predicted phenotypes shows an equal distribution as in Caucasians.

Keywords::

• Caribbean
• CYP2C19
• CYP2D6
• ethnicity
• prevalence
• psychiatry 

Acknowledgements

The authors thank FGM Heijtel and GM Matroos, psychiatrists at the Psychiaters Maatschap Antillen, and also staff at the Klinika Capriles and the psychiatric ward of the local prison in Curaçao for facilitating recruitment.

Financial & competing interests disclosures

This study was funded by ZonMW, The Netherlands Organisation for Health Research and Development (Protocol ID 70–72600–72698–72005). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval and have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, informed consent has been obtained from the participants involved.

Additional information

Funding

This study was funded by ZonMW, The Netherlands Organisation for Health Research and Development (Protocol ID 70–72600–72698–72005). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.