The GNAS SNP c.393C>T (RS7121) as a Marker for Disease Progression and Survival in Cancer

Abstract

G-protein receptor signaling plays a key role in multiple signal transduction pathways. Aberrant activity of the stimulatory G_sα subunit has been frequently associated with cancer. GNAS sequence alterations and conformational changes of G_sα can both enhance or diminish its function and change downstream effects of G-protein receptor signaling. In this review and meta-analysis, we focus on the synonymous SNP rs7121 (FokI, c.393C>T), which is associated with either tumor progression or prolonged survival in cancer patients (overall hazard ratio = 2.256; p < 0.001). We finally point out the relevance of GNAS rs7121 as a promising biomarker and a prediction tool for therapy response and the need of further experiments to implement it into routine clinical diagnostics.

Keywords::

• cancer
• FokI
• GNAS
• progression
• rs7121
• SNP
• survival
• T393C
• therapy response

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.futuremedicine.com/doi/suppl/10.2217/pgs-2018-0199

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript.

No writing assistance was utilized in the production of this manuscript.