Pharmacogenomics Variants are Associated With BMI Differences Between Individuals with Bipolar and Other Psychiatric Disorders

Abstract

Aim: Regardless of the plethora of next-generation sequencingstudies in the field of pharmacogenomics (PGx), the potential effect of covariate variables on PGx response within deeply phenotyped cohorts remains unexplored. Materials & methods: We explored with advanced statistical methods the potential influence of BMI, as a covariate variable, on PGx response in a Greek cohort with psychiatric disorders. Results: Nine PGx variants within UGT1A6, SLC22A4, GSTP1, CYP4B1, CES1, SLC29A3 and DPYD were associated with altered BMI in different psychiatric disorder groups. Carriers of rs2070959 (UGT1A6), rs199861210 (SLC29A3) and rs2297595 (DPYD) were also characterized by significant changes in the mean BMI, depending on the presence of psychiatric disorders. Conclusion: Specific PGx variants are significantly associated with BMI in a Greek cohort with psychiatric disorders.

Keywords::

• ANCOVA
• body mass index
• covariate
• NGS
• pharmacogenes
• psychiatric diseases

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/pgs-2021-0012

Author contributions

GP Patrinos and M Koromina contributed toward conceptualization. A Charalampidi, Z Kordou and M Koromina contributed toward methodology; data curation and writing – original draft preparation; validation. A Charalampidi and M Koromina contributed toward software and investigation. A Charalampidi contributed toward formal analysis and visualization. GP Patrinos, Z Kordou, E-E Tsermpini, P Bosganas, W Chantratita, K Fukunaga and T Mushiroda contributed toward resources. M Koromina and GP Patrinos contributed toward writing – review and editing. GP Patrinos contributed toward supervision; project administration and funding acquisition. All authors have read and agreed to the published version of the manuscript.

Financial & competing interests disclosure

This study was partly funded by a European Commission grant (H2020-668353; U-PGx) to GP Patrinos. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Additional information

Funding

This study was partly funded by a European Commission grant (H2020-668353; U-PGx) to GP Patrinos. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.