Gene Polymorphisms Affect Postoperative Imatinib Plasma Levels and Edema in Adults With Gastrointestinal Stromal Tumor

Abstract

Aim: To assess the role of genetic polymorphisms in postoperative imatinib concentrations and edema in patients with gastrointestinal stromal tumor. Methods: The relationships between genetic polymorphisms, imatinib concentrations and edema were explored. Results: Carriers of the rs683369 G-allele and rs2231142 T-allele had significantly higher imatinib concentrations. Grade ≥2 periorbital edemas were related to the carriership of two C-alleles in rs2072454 with an adjusted odds ratio of 2.85, two T-alleles in rs1867351 with an adjusted odds ratio of 3.42 and two A-alleles in rs11636419 with an adjusted odds ratio of 3.15. Conclusion: rs683369 and rs2231142 affect the metabolism of imatinib; rs2072454, rs1867351 and rs11636419 are related to grade ≥2 periorbital edemas.

Keywords::

• blood concentration
• gastrointestinal stromal tumors
• imatinib
• periorbital edema
• pharmacogenomics

Author contributions

All authors contributed to the manuscript. X Jiang designed this study and drafted the manuscript. Imatinib concentration quantification was done by Y Kong and H Liu. Statistical analysis of data was conducted by X Jiang and Q Fu. K Rexiti, H Peng and P Xiao reviewed data for this study. X Wei critically revised the manuscript.

Acknowledgments

The authors would like to thank Jiangxi Provincial Department of Science and Technology for the provision of financial support and Shanghai Bohao Biological Corporation for the provision of technical support.

Financial & competing interests disclosure

This study was supported by Jiangxi Provincial Department of Science and Technology (no. 20201BBG71008). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

All procedures performed in studies involving human participants were in accordance with the ethical standards of the First Affiliated Hospital of Nanchang University ethics committee (2021 Medical Research Ethics no. 12-001) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individuals included in the study.

Data sharing statement

All datasets used during the study are available from the corresponding author on reasonable request.

Additional information

Funding

This study was supported by Jiangxi Provincial Department of Science and Technology (no. 20201BBG71008). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.