Effect of OPRM1/COMT Gene Polymorphisms on Sufentanil Labor Analgesia: A Cohort Study Based on Propensity Score Matching

Abstract

Background: This study investigated the use of COMT G1947A and OPRM1 A118G polymorphisms as predictive markers for sufentanil epidural analgesia. Methods: The visual analogue scale (VAS) score, and sufentanil consumption of 136 pairs of parturients using sufentanil with lidocaine and ropivacaine for epidural analgesia were used for analysis. Results:OPRM1 AG/GG had lower VAS score difference between fifth and 0 min (1.55 vs 1.87; p = 0.012) and higher consumption (19.65 μg vs 17.11 μg; p = 0.049) than AA carriers. COMT GA/AA had higher VAS score difference than GG carriers (1.86 vs 1.55; p = 0.021). Conclusion: Sufentanil may provide better epidural labor analgesia in OPRM1 AA and COMT GA/AA carriers compared with OPRM1 AG/GG and COMT GG carriers.

Clinical Trial Registration: ChiCTR1900026897 (Chinese Clinical Trial Center Registry)

Keywords::

• analgesia
• COMT
• labor
• OPRM1
• sufentanil

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.futuremedicine.com/doi/suppl/10.2217/pgs-2023-0103

Author contributions

Y Chen, Q Chen and L Wang made substantial contributions to the study design; W Yu, H Huang and W Xie were responsible for collecting medical records and assessing major outcomes; X Lin, M Lin and W Chen were in charge of sample collection; Q Chen, H Wu, T Su and L Wang summarized the data; Q Chen and C Cai conducted the statistical analyses and prepared the figures and tables; Y Chen and L Wang critically revised the manuscript. All authors read and approved the final manuscript.

Financial & competing interests disclosure

This study was supported by the Guiding Project from the Xiamen Municipal Bureau of Science and Technology (no. 3502Z20209197; no. 3502Z20214ZD2149). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The study was approved by the Ethics Council of Human Research in the Xiamen Maternity and Child Health Care Hospital (KY-2019-056). Written informed consent was obtained from all patients.

Data sharing statement

The datasets are available from the corresponding author upon reasonable request.

Additional information

Funding

This study was supported by the Guiding Project from the Xiamen Municipal Bureau of Science and Technology (no. 3502Z20209197; no. 3502Z20214ZD2149). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.